| Title |
The Effect of a Low-Carbohydrate, Ketogenic Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study
|
|---|---|
| Published in |
Digestive Diseases and Sciences, January 2007
|
| DOI | 10.1007/s10620-006-9433-5 |
| Pubmed ID | |
| Authors |
David Tendler, Sauyu Lin, William S. Yancy, John Mavropoulos, Pam Sylvestre, Don C. Rockey, Eric C. Westman |
| Abstract |
Nonalcoholic fatty liver disease is an increasingly common condition that may progress to hepatic cirrhosis. This pilot study evaluated the effects of a low-carbohydrate, ketogenic diet on obesity-associated fatty liver disease. Five patients with a mean body mass index of 36.4 kg/m(2) and biopsy evidence of fatty liver disease were instructed to follow the diet (<20 g/d of carbohydrate) with nutritional supplementation for 6 months. Patients returned for group meetings biweekly for 3 months, then monthly for the second 3 months. The mean weight change was -12.8 kg (range 0 to -25.9 kg). Four of 5 posttreatment liver biopsies showed histologic improvements in steatosis (P=.02) inflammatory grade (P=.02), and fibrosis (P=.07). Six months of a low-carbohydrate, ketogenic diet led to significant weight loss and histologic improvement of fatty liver disease. Further research is into this approach is warranted. |
X Demographics
The data shown below were collected from the profiles of 69 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 22% |
| United Kingdom | 6 | 9% |
| Australia | 4 | 6% |
| Canada | 3 | 4% |
| Colombia | 1 | 1% |
| Côte d'Ivoire | 1 | 1% |
| Saudi Arabia | 1 | 1% |
| Ireland | 1 | 1% |
| Spain | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 32 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 57 | 83% |
| Practitioners (doctors, other healthcare professionals) | 8 | 12% |
| Scientists | 4 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 165 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Spain | 1 | <1% |
| Netherlands | 1 | <1% |
| Kenya | 1 | <1% |
| Unknown | 160 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 15% |
| Researcher | 22 | 13% |
| Student > Master | 21 | 13% |
| Student > Ph. D. Student | 13 | 8% |
| Student > Doctoral Student | 12 | 7% |
| Other | 35 | 21% |
| Unknown | 38 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 55 | 33% |
| Agricultural and Biological Sciences | 15 | 9% |
| Nursing and Health Professions | 11 | 7% |
| Biochemistry, Genetics and Molecular Biology | 11 | 7% |
| Immunology and Microbiology | 4 | 2% |
| Other | 24 | 15% |
| Unknown | 45 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 87. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2024.
All research outputs
#488,576
of 25,457,297 outputs
Outputs from Digestive Diseases and Sciences
#34
of 4,681 outputs
Outputs of similar age
#1,007
of 172,036 outputs
Outputs of similar age from Digestive Diseases and Sciences
#2
of 37 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,681 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.