You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers
|
|---|---|
| Published in |
Carcinogenesis, May 2014
|
| DOI | 10.1093/carcin/bgu114 |
| Pubmed ID | |
| Authors |
Tiffany A Wallace, Ronan F Downey, Caleb J Seufert, Aaron Schetter, Tiffany H Dorsey, Carol A Johnson, Radoslav Goldman, Christopher A Loffredo, Peisha Yan, Francis J Sullivan, Francis J Giles, Feng Wang-Johanning, Stefan Ambs, Sharon A Glynn |
| Abstract |
Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for near intact retroviruses. We hypothesized that HERV-K reactivation could serve as a non-invasive early disease detection marker for prostate cancer. We evaluated HERV-K gag mRNA expression in blood samples of African-American and European-American men using a case-control design via qRT-PCR. Additionally we examined HERV-K envelope protein expression in prostate tumors by immunohistochemistry. HERV-K envelope protein was commonly up-regulated in prostate tumors, but more so in tumors of African-American than European-American patients (61% versus 40%, P < 0.01). Examining HERV-K gag expression in peripheral blood mononuclear cells from 294 cases and 135 healthy men, we found that the abundance of HERV-K gag message was significantly higher in cases than controls, and was associated with increased plasma IFNγ. Men with gag expression in the highest quartile had a greater than 12-fold increased odds [odds ratio = 12.87 (95% CI 6.3-26.25)] of being diagnosed with prostate cancer than those in the lowest quartile. Moreover, our results showed that HERV-K expression may perform better as a disease biomarker in older than younger men (whereas the sensitivity of PSA testing decreases with age), and in men with a smoking history compared with never smokers. Combining non-invasive HERV-K testing with PSA testing may improve the efficacy of prostate cancer detection specifically among older men and smokers who tend to develop a more aggressive disease. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 33% |
| Ireland | 2 | 33% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Scientists | 3 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 74 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 22% |
| Researcher | 15 | 20% |
| Student > Master | 11 | 14% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 5 | 7% |
| Other | 7 | 9% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 14 | 18% |
| Immunology and Microbiology | 8 | 11% |
| Medicine and Dentistry | 6 | 8% |
| Chemistry | 4 | 5% |
| Other | 9 | 12% |
| Unknown | 19 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2020.
All research outputs
#6,440,268
of 25,654,806 outputs
Outputs from Carcinogenesis
#1,538
of 4,910 outputs
Outputs of similar age
#56,266
of 240,543 outputs
Outputs of similar age from Carcinogenesis
#6
of 32 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 4,910 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,543 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.