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Attention Score in Context
| Title |
Ultrasensitive Detection of Human Liver Hepatocellular Carcinoma Cells Using a Label-Free Aptasensor
|
|---|---|
| Published in |
Analytical Chemistry, May 2014
|
| DOI | 10.1021/ac500375p |
| Pubmed ID | |
| Authors |
Leila Kashefi-Kheyrabadi, Masoud A. Mehrgardi, Emilia Wiechec, Anthony P. F. Turner, Ashutosh Tiwari |
| Abstract |
Liver cancer is one of the most common cancers in the world and has no effective cure, especially in later stages. The development of a tangible protocol for early diagnosis of this disease remains a major challenge. In the present manuscript, an aptamer-based, label-free electrochemical biosensor for the sensitive detection of HepG2, a hepatocellular carcinoma cell line, is described. The target cells are captured in a sandwich architecture using TLS11a aptamer covalently attached to a gold surface and a secondary TLS11a aptamer. The application of TLS11a aptamer as a recognition layer resulted in a sensor with high affinity for HepG2 cancer cells in comparison with control cancer cells of human prostate, breast, and colon tumors. The aptasensor delivered a wide linear dynamic range over 1 × 10(2) to 1 × 10(6) cells/mL, with a detection limit of 2 cells/mL. This protocol provides a precise method for sensitive detection of liver cancer with significant advantages in terms of simplicity, low cost, and stability. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Taiwan | 1 | 1% |
| Unknown | 86 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 24% |
| Researcher | 15 | 17% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 7 | 8% |
| Professor | 5 | 6% |
| Other | 15 | 17% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 23 | 26% |
| Biochemistry, Genetics and Molecular Biology | 12 | 14% |
| Agricultural and Biological Sciences | 11 | 13% |
| Engineering | 11 | 13% |
| Physics and Astronomy | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 23 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2014.
All research outputs
#18,372,841
of 22,756,196 outputs
Outputs from Analytical Chemistry
#22,283
of 26,416 outputs
Outputs of similar age
#164,344
of 227,623 outputs
Outputs of similar age from Analytical Chemistry
#231
of 370 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 26,416 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,623 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 370 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.