| Title |
The pharmacogenetics of metformin
|
|---|---|
| Published in |
Diabetologia, August 2017
|
| DOI | 10.1007/s00125-017-4335-y |
| Pubmed ID | |
| Authors |
Jose C. Florez |
| Abstract |
Despite its widespread use as the first-line agent for the treatment of type 2 diabetes, it has become clear that metformin does not work optimally for everyone. Elucidating who are the likely metformin responders and non-responders is hampered by our limited knowledge of its precise molecular mechanism of action. One approach to achieve the related goals of stratifying patients into response subgroups and identifying the molecular targets of metformin involves the deployment of agnostic genome-wide approaches in cohorts of appropriate size to attain sufficient statistical power. While candidate gene studies have shed some light on the role of genetic variation in influencing metformin response, genome-wide association studies are beginning to provide additional insight that is unconstrained by prior knowledge. To fully realise their potential, much larger samples need to be assembled via international collaboration, preferably involving the academic community, government and the pharmaceutical industry. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 13% |
| Spain | 4 | 10% |
| United Kingdom | 4 | 10% |
| Denmark | 3 | 8% |
| Argentina | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Cabo Verde | 1 | 3% |
| Mexico | 1 | 3% |
| Germany | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 16 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 26 | 65% |
| Practitioners (doctors, other healthcare professionals) | 7 | 18% |
| Scientists | 5 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 235 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 235 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 49 | 21% |
| Student > Bachelor | 36 | 15% |
| Researcher | 22 | 9% |
| Student > Ph. D. Student | 19 | 8% |
| Other | 18 | 8% |
| Other | 38 | 16% |
| Unknown | 53 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 58 | 25% |
| Medicine and Dentistry | 40 | 17% |
| Biochemistry, Genetics and Molecular Biology | 27 | 11% |
| Agricultural and Biological Sciences | 17 | 7% |
| Engineering | 6 | 3% |
| Other | 20 | 9% |
| Unknown | 67 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 April 2021.
All research outputs
#1,312,581
of 23,929,753 outputs
Outputs from Diabetologia
#726
of 5,168 outputs
Outputs of similar age
#27,424
of 319,918 outputs
Outputs of similar age from Diabetologia
#37
of 95 outputs
Altmetric has tracked 23,929,753 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,168 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,918 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.