Title |
Real-world adherence and economic outcomes associated with paliperidone palmitate versus oral atypical antipsychotics in schizophrenia patients with substance-related disorders using Medicaid benefits
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Published in |
Journal of Comparative Effectiveness Research, August 2017
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DOI | 10.2217/cer-2017-0043 |
Pubmed ID | |
Authors |
Kruti Joshi, Marie-Hlne Lafeuille, Rhiannon Kamstra, Sean Tiggelaar, Patrick Lefebvre, Edward Kim, Yong Yue, Neeta Tandon |
Abstract |
Compare medication utilization, costs and healthcare resource use in schizophrenia patients with substance-related disorders initiated on once-monthly paliperidone palmitate (PP1M) or an oral atypical antipsychotic (OAA). Data from six Medicaid states (07/2009-03/2015) were used to compare outcomes between PP1M and OAA patients. PP1M patients had higher 12-month antipsychotic adherence and persistence than OAA patients. PP1M patients had lower medical (mean monthly cost difference [MMCD] = US$-191, p = 0.020), higher pharmacy (MMCD = US$250, p < 0.001) and similar total costs (MMCD = US$59, p = 0.517) during the overall follow-up. PP1M patients had lower rates of outpatient visits and inpatient days but higher rates of mental health-related utilization. PP1M was associated with higher antipsychotic adherence and persistence, and similar total costs versus OAA. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 18% |
Student > Master | 5 | 11% |
Student > Bachelor | 4 | 9% |
Student > Ph. D. Student | 3 | 7% |
Other | 2 | 5% |
Other | 4 | 9% |
Unknown | 18 | 41% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 16% |
Psychology | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Social Sciences | 2 | 5% |
Other | 7 | 16% |
Unknown | 19 | 43% |