Title |
Enhanced human receptor binding by H5 haemagglutinins
|
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Published in |
Virology, April 2014
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DOI | 10.1016/j.virol.2014.03.008 |
Pubmed ID | |
Authors |
Xiaoli Xiong, Haixia Xiao, Stephen R. Martin, Peter J. Coombs, Junfeng Liu, Patrick J. Collins, Sebastien G. Vachieri, Philip A. Walker, Yi Pu Lin, John W. McCauley, Steven J. Gamblin, John J. Skehel |
Abstract |
Mutant H5N1 influenza viruses have been isolated from humans that have increased human receptor avidity. We have compared the receptor binding properties of these mutants with those of wild-type viruses, and determined the structures of their haemagglutinins in complex with receptor analogues. Mutants from Vietnam bind tighter to human receptor by acquiring basic residues near the receptor binding site. They bind more weakly to avian receptor because they lack specific interactions between Asn-186 and Gln-226. In contrast, a double mutant, Δ133/Ile155Thr, isolated in Egypt has greater avidity for human receptor while retaining wild-type avidity for avian receptor. Despite these increases in human receptor binding, none of the mutants prefers human receptor, unlike aerosol transmissible H5N1 viruses. Nevertheless, mutants with high avidity for both human and avian receptors may be intermediates in the evolution of H5N1 viruses that could infect both humans and poultry. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 5% |
Unknown | 37 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 23% |
Student > Bachelor | 6 | 15% |
Student > Master | 4 | 10% |
Student > Ph. D. Student | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Other | 5 | 13% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 11 | 28% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Chemistry | 4 | 10% |
Immunology and Microbiology | 3 | 8% |
Medicine and Dentistry | 2 | 5% |
Other | 4 | 10% |
Unknown | 9 | 23% |