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Low expression and secretion of circulating soluble CTLA‐4 in peripheral blood mononuclear cells and sera from type 1 diabetic children

Overview of attention for article published in Diabetes/Metabolism Research and Reviews, January 2012
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Title
Low expression and secretion of circulating soluble CTLA‐4 in peripheral blood mononuclear cells and sera from type 1 diabetic children
Published in
Diabetes/Metabolism Research and Reviews, January 2012
DOI 10.1002/dmrr.1286
Pubmed ID
Authors

Anna Rydén, Caroline Bolmeson, Carl‐Oscar Jonson, Corrado M. Cilio, Maria Faresjö

Abstract

High levels of soluble cytotoxic T-lymphocyte antigen 4 (soluble CTLA-4), an alternative splice form of the regulatory T-cell (Treg) associated CTLA-4 gene, have been associated with type 1 diabetes (T1D) and other autoimmune diseases, such as Grave's disease and myasthenia gravis. At the same time, studies have shown soluble CTLA-4 to inhibit T-cell activation through B7 binding. This study aimed to investigate the role of soluble CTLA-4 in relation to full-length CTLA-4 and other Treg-associated markers in T1D children and in individuals with high or low risk of developing the disease.

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Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 32%
Student > Bachelor 2 11%
Student > Ph. D. Student 2 11%
Professor > Associate Professor 2 11%
Student > Master 2 11%
Other 1 5%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 8 42%
Biochemistry, Genetics and Molecular Biology 2 11%
Agricultural and Biological Sciences 2 11%
Immunology and Microbiology 1 5%
Nursing and Health Professions 1 5%
Other 0 0%
Unknown 5 26%