| Title |
Metformin use in pregnancy: promises and uncertainties
|
|---|---|
| Published in |
Diabetologia, August 2017
|
| DOI | 10.1007/s00125-017-4351-y |
| Pubmed ID | |
| Authors |
Robert S. Lindsay, Mary R. Loeken |
| Abstract |
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies. In early years, perceived safety concerns and lack of availability of the drug in many countries acted as a barrier to use. More recently, RCTs have begun to examine the role of metformin in pregnancy in much-needed detail. However, this evidence base has been interpreted differently in different countries, leading to very wide variation in its current application in pregnancy. In this short review, we will discuss the history of metformin in pregnancy and highlight some of the key clinical trials. We will then consider some of the remaining controversies associated with metformin use in pregnancy, most important of these being the potential for long-term 'programming' effects on the fetus as a result of metformin being able to cross the placenta. We will also consider clinical situations where metformin might be avoided. Finally, we will discuss some future directions for this drug as it reaches its sixtieth anniversary. |
X Demographics
The data shown below were collected from the profiles of 51 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 6 | 12% |
| Canada | 3 | 6% |
| Denmark | 3 | 6% |
| United States | 3 | 6% |
| United Kingdom | 3 | 6% |
| Guatemala | 2 | 4% |
| Australia | 2 | 4% |
| India | 2 | 4% |
| Cabo Verde | 1 | 2% |
| Other | 6 | 12% |
| Unknown | 20 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 69% |
| Scientists | 7 | 14% |
| Practitioners (doctors, other healthcare professionals) | 7 | 14% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 186 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 186 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 15% |
| Researcher | 17 | 9% |
| Student > Master | 17 | 9% |
| Student > Ph. D. Student | 16 | 9% |
| Student > Postgraduate | 13 | 7% |
| Other | 36 | 19% |
| Unknown | 59 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 67 | 36% |
| Pharmacology, Toxicology and Pharmaceutical Science | 16 | 9% |
| Biochemistry, Genetics and Molecular Biology | 12 | 6% |
| Nursing and Health Professions | 7 | 4% |
| Agricultural and Biological Sciences | 5 | 3% |
| Other | 19 | 10% |
| Unknown | 60 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2020.
All research outputs
#1,326,730
of 25,346,731 outputs
Outputs from Diabetologia
#711
of 5,341 outputs
Outputs of similar age
#26,019
of 323,536 outputs
Outputs of similar age from Diabetologia
#35
of 94 outputs
Altmetric has tracked 25,346,731 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,341 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.