Title |
Human Papillomavirus 16, 18, 31 and 45 viral load, integration and methylation status stratified by cervical disease stage
|
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Published in |
BMC Cancer, May 2014
|
DOI | 10.1186/1471-2407-14-384 |
Pubmed ID | |
Authors |
Luigi Marongiu, Anna Godi, John V Parry, Simon Beddows |
Abstract |
Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical disease. HPV DNA testing offers improved sensitivity over cytology testing alone but is accompanied by a generally low specificity. Potential molecular markers of cervical disease include type-specific viral load (VL), integration of HPV DNA into the host genome and methylation of the HPV genome. The aim of this study was to evaluate the relationship between HPV type-specific viral load, integration and methylation status and cervical disease stage in samples harboring HPV16, HPV18, HPV31 or HPV45. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
France | 1 | 2% |
Unknown | 58 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 17% |
Researcher | 9 | 15% |
Student > Bachelor | 8 | 13% |
Student > Master | 8 | 13% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 13% |
Unknown | 13 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 23% |
Medicine and Dentistry | 13 | 22% |
Agricultural and Biological Sciences | 9 | 15% |
Nursing and Health Professions | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 3 | 5% |
Unknown | 15 | 25% |