Title |
Endocrine therapy: defining the path of least resistance
|
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Published in |
Breast Cancer Research, May 2014
|
DOI | 10.1186/bcr3659 |
Pubmed ID | |
Authors |
Andrew Stone, Elizabeth A Musgrove |
Abstract |
One of the best-characterized oncogenic mechanisms in breast cancer is the aberrant activation of phosphatidylinositol-3-kinase, protein kinase B, and mammalian target of rapamycin signaling. In both endocrine-resistant disease and breast cancer stem cells, this is commonly caused by specific genetic lesions or amplification of key pathway components or both. These observations have generated two interesting hypotheses. Firstly, do these genetic anomalies provide clinically significant biomarkers predictive of endocrine resistance? Secondly, do tamoxifen-resistant breast cancer cells emerge from a stem-like cell population? New studies, published in Breast Cancer Research, raise the possibility that these hypotheses are intrinsically linked. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 33% |
Other | 2 | 17% |
Student > Master | 2 | 17% |
Professor | 1 | 8% |
Student > Postgraduate | 1 | 8% |
Other | 0 | 0% |
Unknown | 2 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 33% |
Agricultural and Biological Sciences | 3 | 25% |
Medicine and Dentistry | 2 | 17% |
Chemical Engineering | 1 | 8% |
Unknown | 2 | 17% |