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Electronic control of platelet adhesion using conducting polymer microarrays

Overview of attention for article published in Lab on a Chip - Miniaturisation for Chemistry & Biology, June 2014
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Title
Electronic control of platelet adhesion using conducting polymer microarrays
Published in
Lab on a Chip - Miniaturisation for Chemistry & Biology, June 2014
DOI 10.1039/c4lc00201f
Pubmed ID
Authors

Lars Faxälv, Maria H. Bolin, Edwin W. H. Jager, Tomas L. Lindahl, Magnus Berggren

Abstract

We hereby report a method to fabricate addressable micropatterns of e-surfaces based on the conducting polymer poly(3,4-ethylenedioxythiophene) doped with the anion tosylate (PEDOT:Tos) to gain dynamic control over the spatial distribution of platelets in vitro. With thin film processing and microfabrication techniques, patterns down to 10 μm were produced to enable active regulation of platelet adhesion at high spatial resolution. Upon electronic addressing, both reduced and oxidized surfaces were created within the same device. This surface modulation dictates the conformation and/or orientation, rather than the concentration, of surface proteins, thus indirectly regulating the adhesion of platelets. The reduced electrode supported platelet adhesion, whereas the oxidized counterpart inhibited adhesion. PEDOT:Tos electrode fabrication is compatible with most of the classical patterning techniques used in printing as well as in the electronics industry. The first types of tools promise ultra-low-cost production of low-resolution (>30 μm) electrode patterns that may combine with traditional substrates and dishes used in a classical analysis setup. Platelets play a pronounced role in cardiovascular diseases and have become an important drug target in order to prevent thrombosis. This clinical path has in turn generated a need for platelet function tests to monitor and assess platelet drug efficacy. The spatial control of platelet adherence presented here could prove valuable for blood cell separation or biosensor microarrays, e.g. in diagnostic applications where platelet function is evaluated.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Greece 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 26%
Professor 3 13%
Student > Ph. D. Student 3 13%
Student > Master 3 13%
Student > Postgraduate 2 9%
Other 4 17%
Unknown 2 9%
Readers by discipline Count As %
Engineering 8 35%
Chemistry 3 13%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Physics and Astronomy 2 9%
Materials Science 2 9%
Other 3 13%
Unknown 3 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2014.
All research outputs
#16,781,609
of 25,457,297 outputs
Outputs from Lab on a Chip - Miniaturisation for Chemistry & Biology
#4,488
of 5,941 outputs
Outputs of similar age
#140,424
of 243,104 outputs
Outputs of similar age from Lab on a Chip - Miniaturisation for Chemistry & Biology
#34
of 51 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,941 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,104 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.