Title |
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes
|
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Published in |
Arthritis Research & Therapy, May 2014
|
DOI | 10.1186/ar4564 |
Pubmed ID | |
Authors |
Fatima Ezzahra El Mansouri, Salwa-Sarah Nebbaki, Mohit Kapoor, Hassan Afif, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Mohamed Benderdour, Hassan Fahmi |
Abstract |
Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step in the biosynthesis of PGE2, a critical mediator in the pathophysiology of osteoarthritis (OA). Histone methylation plays an important role in epigenetic gene regulation. In this study, we investigated the roles of histone H3 (H3K9) methylation in interleukin-1beta (IL-1beta)-induced mPGES-1 expression in human chondrocytes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 3% |
United States | 1 | 3% |
Unknown | 31 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 18% |
Researcher | 5 | 15% |
Student > Ph. D. Student | 4 | 12% |
Other | 3 | 9% |
Student > Doctoral Student | 3 | 9% |
Other | 5 | 15% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 21% |
Agricultural and Biological Sciences | 7 | 21% |
Medicine and Dentistry | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 4 | 12% |
Unknown | 11 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2014.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#3,132
of 3,381 outputs
Outputs of similar age
#209,211
of 241,958 outputs
Outputs of similar age from Arthritis Research & Therapy
#35
of 40 outputs
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