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Autoinducer-2 Plays a Crucial Role in Gut Colonization and Probiotic Functionality of Bifidobacterium breve UCC2003

Overview of attention for article published in PLOS ONE, May 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

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4 X users
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37 patents

Citations

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Title
Autoinducer-2 Plays a Crucial Role in Gut Colonization and Probiotic Functionality of Bifidobacterium breve UCC2003
Published in
PLOS ONE, May 2014
DOI 10.1371/journal.pone.0098111
Pubmed ID
Authors

Steven E. A. Christiaen, Mary O'Connell Motherway, Francesca Bottacini, Noreen Lanigan, Pat G. Casey, Geert Huys, Hans J. Nelis, Douwe van Sinderen, Tom Coenye

Abstract

In the present study we show that luxS of Bifidobacterium breve UCC2003 is involved in the production of the interspecies signaling molecule autoinducer-2 (AI-2), and that this gene is essential for gastrointestinal colonization of a murine host, while it is also involved in providing protection against Salmonella infection in Caenorhabditis elegans. We demonstrate that a B. breve luxS-insertion mutant is significantly more susceptible to iron chelators than the WT strain and that this sensitivity can be partially reverted in the presence of the AI-2 precursor DPD. Furthermore, we show that several genes of an iron starvation-induced gene cluster, which are downregulated in the luxS-insertion mutant and which encodes a presumed iron-uptake system, are transcriptionally upregulated under in vivo conditions. Mutation of two genes of this cluster in B. breve UCC2003 renders the derived mutant strains sensitive to iron chelators while deficient in their ability to confer gut pathogen protection to Salmonella-infected nematodes. Since a functional luxS gene is present in all tested members of the genus Bifidobacterium, we conclude that bifidobacteria operate a LuxS-mediated system for gut colonization and pathogen protection that is correlated with iron acquisition.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 1%
Argentina 1 1%
Unknown 82 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 24%
Student > Ph. D. Student 16 19%
Student > Master 9 11%
Student > Bachelor 7 8%
Other 5 6%
Other 11 13%
Unknown 16 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 32%
Immunology and Microbiology 15 18%
Biochemistry, Genetics and Molecular Biology 13 15%
Medicine and Dentistry 4 5%
Chemistry 2 2%
Other 4 5%
Unknown 19 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#5,640,842
of 23,269,984 outputs
Outputs from PLOS ONE
#70,712
of 198,842 outputs
Outputs of similar age
#51,998
of 227,971 outputs
Outputs of similar age from PLOS ONE
#1,222
of 4,526 outputs
Altmetric has tracked 23,269,984 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 198,842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,971 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 4,526 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.