| Title |
Identifying cisplatin-induced kidney damage in paediatric oncology patients
|
|---|---|
| Published in |
Pediatric Nephrology, August 2017
|
| DOI | 10.1007/s00467-017-3765-6 |
| Pubmed ID | |
| Authors |
Chris D. Barton, Barry Pizer, Caroline Jones, Louise Oni, Munir Pirmohamed, Daniel B. Hawcutt |
| Abstract |
Cisplatin is one chemotherapeutic agent used to treat childhood cancer in numerous treatment protocols, including as a single agent. It is likely to remain in clinical use over the long term. However, cisplatin-related toxicities, including neurotoxicity and nephrotoxicity, are common, affecting treatment, day-to-day life and survival of such children. With one in 700 young adults having survived childhood cancer, patients who have completed chemotherapy that includes cisplatin can experience long-term morbidity due to treatment-related adverse reactions. A better understanding of these toxicities is essential to facilitate prevention, surveillance and management. This review article discusses the effect of cisplatin-induced nephrotoxicity (Cis-N) in children and considers the underlying mechanisms. We focus on clinical features and identification of Cis-N (e.g. investigations and biomarkers) and the importance of magnesium homeostasis and supplementation. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 22% |
| United States | 2 | 22% |
| Mexico | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Practitioners (doctors, other healthcare professionals) | 2 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 67 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 18% |
| Student > Ph. D. Student | 8 | 12% |
| Student > Bachelor | 7 | 10% |
| Researcher | 6 | 9% |
| Other | 5 | 7% |
| Other | 8 | 12% |
| Unknown | 21 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 28% |
| Nursing and Health Professions | 10 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 13% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Computer Science | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 24 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2017.
All research outputs
#5,450,480
of 22,997,544 outputs
Outputs from Pediatric Nephrology
#844
of 3,579 outputs
Outputs of similar age
#85,290
of 318,830 outputs
Outputs of similar age from Pediatric Nephrology
#17
of 86 outputs
Altmetric has tracked 22,997,544 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,579 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,830 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.