Proteomics for Drug Discovery

Chapter 1 A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates

Chapter 2 Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins

Chapter 3 Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics

Chapter 4 High-Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators

Chapter 5 Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery

Chapter 6 Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules

Chapter 7 Microfluidics-Mass Spectrometry of Protein-Carbohydrate Interactions: Applications to the Development of Therapeutics and Biomarker Discovery

Chapter 8 Studying Protein–Protein Interactions by Biotin AP-Tagged Pulldown and LTQ-Orbitrap Mass Spectrometry

Chapter 9 Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation

Chapter 10 Reverse Phase Protein Arrays and Drug Discovery

Chapter 11 Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog

Chapter 12 Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy

Chapter 13 Identification of Lipid Binding Modulators Using the Protein-Lipid Overlay Assay

Chapter 14 Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity Results

Chapter 15 Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows

Chapter 16 Method to Identify Silent Codon Mutations That May Alter Peptide Elongation Kinetics and Co-translational Protein Folding

Chapter 17 In Silico Design of Anticancer Peptides

Chapter 18 Docking and Virtual Screening in Drug Discovery

Chapter 19 Bioinformatics Resources for Interpreting Proteomics Mass Spectrometry Data

Chapter 20 Erratum to: Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog