| Title |
Effects of testosterone treatment on hypothalamic neuroplasticity in female-to-male transgender individuals
|
|---|---|
| Published in |
Brain Structure and Function, August 2017
|
| DOI | 10.1007/s00429-017-1494-z |
| Pubmed ID | |
| Authors |
Georg S. Kranz, Andreas Hahn, Ulrike Kaufmann, Martin Tik, Sebastian Ganger, René Seiger, Allan Hummer, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger |
| Abstract |
Diffusion-weighted imaging (DWI) is used to measure gray matter tissue density and white matter fiber organization/directionality. Recent studies show that DWI also allows for assessing neuroplastic adaptations in the human hypothalamus. To this end, we investigated a potential influence of testosterone replacement therapy on hypothalamic microstructure in female-to-male (FtM) transgender individuals. 25 FtMs were measured at baseline, 4 weeks, and 4 months past treatment start and compared to 25 female and male controls. Our results show androgenization-related reductions in mean diffusivity in the lateral hypothalamus. Significant reductions were observed unilaterally after 1 month and bilaterally after 4 months of testosterone treatment. Moreover, treatment induced increases in free androgen index and bioavailable testosterone were significantly associated with the magnitude of reductions in mean diffusivity. These findings imply microstructural plasticity and potentially related changes in neural activity by testosterone in the adult human hypothalamus and suggest that testosterone replacement therapy in FtMs changes hypothalamic microstructure towards male proportions. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 14% |
| Canada | 1 | 5% |
| Netherlands | 1 | 5% |
| Mexico | 1 | 5% |
| United Kingdom | 1 | 5% |
| Unknown | 14 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 19 | 90% |
| Scientists | 1 | 5% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 57 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 18% |
| Student > Bachelor | 6 | 11% |
| Student > Doctoral Student | 6 | 11% |
| Other | 4 | 7% |
| Student > Ph. D. Student | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 20 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 11 | 19% |
| Medicine and Dentistry | 11 | 19% |
| Neuroscience | 8 | 14% |
| Nursing and Health Professions | 1 | 2% |
| Social Sciences | 1 | 2% |
| Other | 3 | 5% |
| Unknown | 22 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 June 2023.
All research outputs
#2,302,152
of 25,760,414 outputs
Outputs from Brain Structure and Function
#141
of 2,044 outputs
Outputs of similar age
#42,249
of 328,170 outputs
Outputs of similar age from Brain Structure and Function
#5
of 41 outputs
Altmetric has tracked 25,760,414 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,044 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,170 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.