Title |
Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis
|
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Published in |
Obesity Surgery, August 2017
|
DOI | 10.1007/s11695-017-2857-5 |
Pubmed ID | |
Authors |
Fabio Bustamante, Vitor Ottoboni Brunaldi, Wanderley Marques Bernardo, Diogo Turiani H. de Moura, Eduardo Turiani H. de Moura, Manoel Galvão, Marco Aurélio Santo, Eduardo Guimarães H. de Moura |
Abstract |
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, - 1.14, 1.38] and - 0.06 [95% CI, - 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 14% |
Comoros | 1 | 14% |
Egypt | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 17% |
Other | 6 | 17% |
Student > Postgraduate | 3 | 9% |
Student > Master | 3 | 9% |
Student > Ph. D. Student | 2 | 6% |
Other | 6 | 17% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 14 | 40% |
Nursing and Health Professions | 3 | 9% |
Engineering | 2 | 6% |
Psychology | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 6% |
Unknown | 12 | 34% |