Title |
Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers
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Published in |
Endocrine-Related Cancer, May 2014
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DOI | 10.1530/erc-14-0234 |
Pubmed ID | |
Authors |
Luke A Selth, Matthew J Roberts, Clement W K Chow, Villis R Marshall, Suhail A R Doi, Andrew D Vincent, Lisa M Butler, Martin F Lavin, Wayne D Tilley, Robert A Gardiner |
Abstract |
Extract: Prostate cancer (PCa) is the most commonly diagnosed malignancy among men living in Western countries and a major cause of cancer-related deaths. Biopsy-based diagnosis of PCa is usually undertaken following an elevated serum prostate specific antigen (PSA) measurement and/or abnormal digital rectal examination (DRE). The deficiencies of serum PSA as a biomarker have been well documented (Roobol and Carlsson 2013). While it is highly specific for tissue of prostatic origin, PSA is not cancer-specific, resulting in many unnecessary biopsies of benign disease. Moreover, PSA screening has resulted in substantial over-diagnosis and over-treatment of indolent tumours without having a significant effect on prostate cancer mortality (Schroder, et al. 2009). Biomarkers that could identify patients with clinically significant PCa would be ideal but are currently lacking ... |
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Ireland | 1 | 14% |
United Kingdom | 1 | 14% |
Canada | 1 | 14% |
United States | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
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Denmark | 1 | 2% |
Unknown | 51 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 21% |
Researcher | 9 | 17% |
Student > Bachelor | 8 | 15% |
Student > Doctoral Student | 3 | 6% |
Student > Postgraduate | 3 | 6% |
Other | 6 | 12% |
Unknown | 12 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 21% |
Biochemistry, Genetics and Molecular Biology | 9 | 17% |
Engineering | 3 | 6% |
Chemical Engineering | 1 | 2% |
Other | 1 | 2% |
Unknown | 16 | 31% |