Title |
Evaluation of global circumferential strain as prognostic marker after administration of β-blockers for dilated cardiomyopathy
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Published in |
The International Journal of Cardiovascular Imaging, June 2014
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DOI | 10.1007/s10554-014-0463-3 |
Pubmed ID | |
Authors |
Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Tatsuya Miyoshi, Yoshiki Motoji, Junichi Imanishi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Ken-ichi Hirata |
Abstract |
The use of β-blockers has improved the prognosis of dilated cardiomyopathy (DCM) and the appearance of left ventricular (LV) reverse remodeling is generally thought to result in a more favorable prognosis. While there are many prognostic predictors, not all of them are applicable to individual patients. Global circumferential strain (GCS) was identified as a powerful prognostic marker, which appears to be a better parameter than LV global function for patients with depressed left ventricular (LV) ejection fraction. Seventy consecutive patients with newly-diagnosed DCM with LVEF of 28 ± 8 % (all <45 %) were retrospectively recruited. Either carvedilol or bisoprolol was titrated to a dose that was tolerable for each of the patients. GCS was determined as the peak global speckle-tracking circumferential strain from the mid-LV short-axis view. LV reverse remodeling was defined as an absolute increase in LVEF of at least 10 % during 8.1 ± 5.2-month follow-up after initiation of the maintenance dose of β-blockers. GCS ≥ 5.4 % was identified as the best predictor of LV reverse remodeling with 91 % sensitivity and 82 % specificity, and an area under the curve of 0.896 (p < 0.0001). An important finding of multivariate logistic regression analysis was that GCS was the best independent predictor of LV reverse remodeling (OR 7.692; 95 % CI 2.292-25.82; p = 0.001). It should be noted that only 1.3 ± 0.4 min per patient was needed to analyze GCS. In conclusions, GCS could result in further improvements in predicting LV reverse remodeling after β-blocker administration, and have clinical implications for better management in daily clinical practice. |
X Demographics
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Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 23% |
Student > Master | 5 | 16% |
Researcher | 5 | 16% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Other | 4 | 13% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 21 | 68% |
Neuroscience | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Nursing and Health Professions | 1 | 3% |
Chemistry | 1 | 3% |
Other | 1 | 3% |
Unknown | 3 | 10% |