| Title |
Perspective of ions and messengers: an intricate link between potassium, glutamate, and cyclic di-AMP
|
|---|---|
| Published in |
Current Genetics, August 2017
|
| DOI | 10.1007/s00294-017-0734-3 |
| Pubmed ID | |
| Authors |
Jan Gundlach, Fabian M. Commichau, Jörg Stülke |
| Abstract |
Potassium and glutamate are the most abundant ions in every living cell. Whereas potassium plays a major role to keep the cellular turgor and to buffer the negative charges of the nucleic acids, the major function of glutamate is to serve as the universal amino group donor. In addition, both ions are involved in osmoprotection in bacterial cells. Here, we discuss how bacterial cells maintain the homeostasis of both ions and how adaptive evolution allows them to live even at extreme potassium limitation. Interestingly, positively charged amino acids are able to partially replace potassium, likely by buffering the negative charge of DNA. A major factor involved in the control of potassium homeostasis in Gram-positive bacteria is the essential second messenger cyclic di-AMP. This nucleotide is synthesized in response to the potassium concentration and in turn controls the expression and activity of potassium transporters. We discuss the link between the two major ions, DNA and the second messenger c-di-AMP. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Student > Bachelor | 8 | 16% |
| Student > Master | 7 | 14% |
| Researcher | 6 | 12% |
| Student > Doctoral Student | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 21 | 42% |
| Agricultural and Biological Sciences | 7 | 14% |
| Immunology and Microbiology | 4 | 8% |
| Chemistry | 2 | 4% |
| Linguistics | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 13 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
All research outputs
#20,025,277
of 25,476,463 outputs
Outputs from Current Genetics
#966
of 1,234 outputs
Outputs of similar age
#237,637
of 326,113 outputs
Outputs of similar age from Current Genetics
#14
of 23 outputs
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So far Altmetric has tracked 1,234 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
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