| Title |
Developmentally regulated signaling pathways in glioma invasion
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, August 2017
|
| DOI | 10.1007/s00018-017-2608-8 |
| Pubmed ID | |
| Authors |
Shwetal Mehta, Costanza Lo Cascio |
| Abstract |
Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The grim prognosis for this disease is due to a combination of the presence of highly invasive tumor cells that escape surgical resection and the presence of a population of therapy-resistant cancer stem cells found within these tumors. Several studies suggest that glioma cells have cleverly hijacked the normal developmental program of neural progenitor cells, including their transcriptional programs, to enhance gliomagenesis. In this review, we summarize the role of developmentally regulated signaling pathways that have been found to facilitate glioma growth and invasion. Furthermore, we discuss how the microenvironment and treatment-induced perturbations of these highly interconnected signaling networks can trigger a shift in cellular phenotype and tumor subtype. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Science communicators (journalists, bloggers, editors) | 2 | 40% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 105 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 23% |
| Researcher | 15 | 14% |
| Student > Bachelor | 11 | 10% |
| Student > Master | 10 | 10% |
| Student > Doctoral Student | 4 | 4% |
| Other | 13 | 12% |
| Unknown | 28 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 25 | 24% |
| Medicine and Dentistry | 18 | 17% |
| Agricultural and Biological Sciences | 11 | 10% |
| Neuroscience | 6 | 6% |
| Engineering | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 32 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2018.
All research outputs
#14,050,687
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#2,714
of 4,151 outputs
Outputs of similar age
#163,776
of 320,050 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#24
of 54 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.