| Title |
Metformin and ageing: improving ageing outcomes beyond glycaemic control
|
|---|---|
| Published in |
Diabetologia, August 2017
|
| DOI | 10.1007/s00125-017-4349-5 |
| Pubmed ID | |
| Authors |
Willy Marcos Valencia, Ana Palacio, Leonardo Tamariz, Hermes Florez |
| Abstract |
In a world where the population is ageing, there is growing interest and demand for research evaluating strategies that address the ageing process. After 60 years of successful use of metformin in our pharmaceutical armamentarium, we are learning that, beyond improving glycaemic control, metformin may have additional mechanisms and pathways of action that need further study. Although, metformin's effect on clinical ageing outcomes may still be considered speculative, the findings from studies into cellular and animal models and from observational and pilot human studies support the existence of beneficial effects on ageing. At present, progress for human research, using randomised clinical trials to evaluate metformin's clinical impact, has just started. Here, we present a review on the ageing process and the mechanisms involved, and the role that metformin may have to counter these. We go on to discuss the upcoming large randomised clinical trials that may provide insight on the use of metformin for ageing outcomes beyond glycaemic control. |
X Demographics
The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 9% |
| United Kingdom | 4 | 9% |
| Germany | 3 | 7% |
| Belgium | 2 | 4% |
| Spain | 2 | 4% |
| India | 1 | 2% |
| Indonesia | 1 | 2% |
| Venezuela, Bolivarian Republic of | 1 | 2% |
| Denmark | 1 | 2% |
| Other | 6 | 13% |
| Unknown | 20 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 73% |
| Scientists | 6 | 13% |
| Practitioners (doctors, other healthcare professionals) | 5 | 11% |
| Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 159 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 15% |
| Student > Bachelor | 21 | 13% |
| Student > Master | 17 | 11% |
| Student > Ph. D. Student | 15 | 9% |
| Other | 12 | 8% |
| Other | 22 | 14% |
| Unknown | 48 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 38 | 24% |
| Biochemistry, Genetics and Molecular Biology | 26 | 16% |
| Agricultural and Biological Sciences | 14 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 5% |
| Engineering | 5 | 3% |
| Other | 14 | 9% |
| Unknown | 54 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#1,113,730
of 25,554,853 outputs
Outputs from Diabetologia
#583
of 5,361 outputs
Outputs of similar age
#22,259
of 327,643 outputs
Outputs of similar age from Diabetologia
#30
of 94 outputs
Altmetric has tracked 25,554,853 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,361 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.7. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,643 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.