Title |
Nutrients, Clock Genes, and Chrononutrition
|
---|---|
Published in |
Current Nutrition Reports, April 2014
|
DOI | 10.1007/s13668-014-0082-6 |
Pubmed ID | |
Authors |
Hideaki Oike, Katsutaka Oishi, Masuko Kobori |
Abstract |
Circadian clocks that comprise clock genes exist throughout the body and control daily physiological events. The central clock that dominates activity rhythms is entrained by light/dark cycles, whereas peripheral clocks regulating local metabolic rhythms are determined by feeding/fasting cycles. Nutrients reset peripheral circadian clocks and the local clock genes control downstream metabolic processes. Metabolic states also affect the clockworks in feedback manners. Because the circadian system organizes whole energy homeostasis, including food intake, fat accumulation, and caloric expenditure, the disruption of circadian clocks leads to metabolic disorders. Recent findings show that time-restricted feeding during the active phase amplifies circadian clocks and improves metabolic disorders induced by a high-fat diet without caloric reduction, whereas unusual/irregular food intake induces various metabolic dysfunctions. Such evidence from nutrition studies that consider circadian system (chrononutrition) has rapidly accumulated. We review molecular relationships between circadian clocks and nutrition as well as recent chrononutrition findings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 11 | 20% |
United Kingdom | 4 | 7% |
United States | 3 | 5% |
Argentina | 3 | 5% |
Mexico | 2 | 4% |
Guinea | 1 | 2% |
Australia | 1 | 2% |
Colombia | 1 | 2% |
Unknown | 30 | 54% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 44 | 79% |
Practitioners (doctors, other healthcare professionals) | 7 | 13% |
Scientists | 4 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | <1% |
Spain | 2 | <1% |
Brazil | 2 | <1% |
Sweden | 1 | <1% |
South Africa | 1 | <1% |
Germany | 1 | <1% |
Mexico | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Other | 1 | <1% |
Unknown | 441 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 77 | 17% |
Student > Master | 68 | 15% |
Researcher | 41 | 9% |
Student > Ph. D. Student | 41 | 9% |
Other | 23 | 5% |
Other | 75 | 17% |
Unknown | 129 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 67 | 15% |
Nursing and Health Professions | 47 | 10% |
Biochemistry, Genetics and Molecular Biology | 44 | 10% |
Neuroscience | 18 | 4% |
Other | 55 | 12% |
Unknown | 155 | 34% |