Title |
Weight loss in neurodegenerative disorders
|
---|---|
Published in |
Journal of Neurology, January 2009
|
DOI | 10.1007/s00415-009-0062-8 |
Pubmed ID | |
Authors |
N. A. Aziz, M. A. van der Marck, H. Pijl, M. G. M. Olde Rikkert, B. R. Bloem, R. A. C. Roos |
Abstract |
Unintended weight loss frequently complicates the course of many neurodegenerative disorders and can contribute substantially to both morbidity and mortality. This will be illustrated here by reviewing the characteristics of unintended weight loss in the three major neurodegenerative disorders: Alzheimer's disease, Parkinson's disease and Huntington's disease. A common denominator of weight loss in these neurodegenerative disorders is its typically complex pathophysiology. Timely recognition of the underlying pathophysiological process is of crucial importance, since a tailored treatment of weight loss can considerably improve the quality of life. This treatment is, primarily, comprised of a number of methods of increasing energy intake. Moreover, there are indications for defects in the systemic energy homeostasis and gastrointestinal function, which may also serve as therapeutic targets. However, the clinical merits of such interventions have yet to be demonstrated. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 1 | <1% |
Austria | 1 | <1% |
Unknown | 142 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 27 | 18% |
Student > Ph. D. Student | 26 | 18% |
Researcher | 18 | 12% |
Student > Master | 14 | 9% |
Student > Doctoral Student | 8 | 5% |
Other | 28 | 19% |
Unknown | 27 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 37 | 25% |
Neuroscience | 20 | 14% |
Agricultural and Biological Sciences | 18 | 12% |
Biochemistry, Genetics and Molecular Biology | 9 | 6% |
Nursing and Health Professions | 9 | 6% |
Other | 20 | 14% |
Unknown | 35 | 24% |