| Title |
A pilot study comparing T-regulatory cell function among healthy children in different areas of Gansu, China
|
|---|---|
| Published in |
Environmental Science and Pollution Research, August 2017
|
| DOI | 10.1007/s11356-017-9907-3 |
| Pubmed ID | |
| Authors |
Panhong Gou, Xiaoru Chang, Zhonghui Ye, Yueli Yao, Patton Khuu Nguyen, Sally Katharine Hammond, Junling Wang, Sa Liu |
| Abstract |
Immune system is critical to protecting human health from toxic substances. Our previously published research had found an important link between polycyclic aromatic hydrocarbons (PAHs) in ambient air and changes at the DNA level in immune cells that led to impaired function of regulatory T (Treg) cells in children living in California, USA. But molecular and cellular pathways of these changes remain unclear. The present study aims to explore whether exposure to PAHs leads to changes in Treg cells functions of children living in Gansu, China, where ambient air pollution levels are much higher than those in California, and to explore potential mechanisms of PAH-induced immunological dysfunctions. Air pollutions in Lanzhou and Lintao, Gansu Province, were measured from December 2015 to June 2016. Healthy children were recruited from both cities and enrolled in this pilot study. Demographic information was collected by questionnaires. Blood samples were collected. Peripheral blood Treg cells were analyzed for Treg cells percentage by flow cytometry. Gene expression of forkhead box transcription factor 3 (Foxp3), transforming growth factor-β (TGF-β), and interleukin 35 (IL35) were examined by reverse transcription-polymerase chain reaction (RT-PCR). The results indicated PAH concentration (as sum of 16 PAHs) in Lintao was over two times higher than that was in Lanzhou (707 vs. 326 ng/m(3)), whereas PM2.5 concentration was comparable in two cities (55.3 in Lintao vs. 65.7 μg/m(3) in Lanzhou). Notably, we observed lower gene expressions for Foxp3 (P < 0.05), IL35 (P < 0.05), and TGF-β, in children living in Lintao, suggesting an impairment of Treg cells function potentially associated with higher PAH exposure in Lintao. However, no significant difference was observed in Treg cells % among CD4(+) T cells between Lanzhou and Lintao groups. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 15% |
| Student > Bachelor | 1 | 8% |
| Student > Postgraduate | 1 | 8% |
| Student > Master | 1 | 8% |
| Unknown | 8 | 62% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 3 | 23% |
| Medicine and Dentistry | 2 | 15% |
| Social Sciences | 1 | 8% |
| Unknown | 7 | 54% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2017.
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#18,756,367
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Outputs from Environmental Science and Pollution Research
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Outputs of similar age
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Outputs of similar age from Environmental Science and Pollution Research
#110
of 212 outputs
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