| Title |
Relationships between cardiorespiratory fitness, metabolic control, and fat distribution in type 2 diabetes subjects
|
|---|---|
| Published in |
Acta Diabetologica, October 2013
|
| DOI | 10.1007/s00592-013-0519-1 |
| Pubmed ID | |
| Authors |
Elisabetta Bacchi, Carlo Negri, Cantor Tarperi, Anna Baraldo, Niccolò Faccioli, Chiara Milanese, Maria Elisabetta Zanolin, Massimo Lanza, Antonio Cevese, Enzo Bonora, Federico Schena, Paolo Moghetti |
| Abstract |
Factors contributing to the reduced cardiorespiratory fitness typical of sedentary subjects with type 2 diabetes are still largely unknown. In this study, we assessed the relationships between cardiorespiratory fitness and abdominal and skeletal muscle fat content in 39 untrained type 2 diabetes subjects, 27 males and 12 females (mean ± SD age 56.5 ± 7.3 year, BMI 29.4 ± 4.7 kg/m(2)). Peak oxygen uptake (VO2peak) and ventilatory threshold (VO2VT) were assessed by maximal cycle ergometer exercise test, insulin sensitivity by euglycemic-hyperinsulinemic clamp, and body composition by dual-energy X-ray absorptiometry. Magnetic resonance imaging was used to evaluate visceral, total subcutaneous (SAT), superficial (SSAT) and deep sub-depots of subcutaneous abdominal adipose tissue, and sagittal abdominal diameter (SAD), as well as femoral quadriceps skeletal muscle fat content. In univariate analysis, both VO2peak and VO2VT were inversely associated with BMI, total fat mass, SAT, SSAT, and sagittal abdominal diameter. VO2peak was also inversely associated with skeletal muscle fat content. A significant direct association was observed between VO2VT and insulin sensitivity. No associations between cardiorespiratory fitness parameters and metabolic profile data were found. In multivariable regression analysis, after adjusting for age and gender, VO2peak was independently predicted by higher HDL cholesterol, and lower SAD and skeletal muscle fat content (R (2) = 0.64, p < 0.001), whereas VO2VT was predicted only by sagittal abdominal diameter (R (2) = 0.48, p = 0.025). In conclusion, in untrained type 2 diabetes subjects, peak oxygen uptake is associated with sagittal abdominal diameter, skeletal muscle fat content, and HDL cholesterol levels. Future research should target these features in prospective intervention studies. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Denmark | 1 | 1% |
| Unknown | 83 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 19% |
| Student > Master | 11 | 13% |
| Student > Ph. D. Student | 9 | 11% |
| Researcher | 8 | 9% |
| Student > Postgraduate | 6 | 7% |
| Other | 19 | 22% |
| Unknown | 16 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 26% |
| Sports and Recreations | 15 | 18% |
| Nursing and Health Professions | 10 | 12% |
| Agricultural and Biological Sciences | 7 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 15 | 18% |
| Unknown | 13 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from Acta Diabetologica
#720
of 889 outputs
Outputs of similar age
#184,004
of 210,774 outputs
Outputs of similar age from Acta Diabetologica
#6
of 6 outputs
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