Title |
B7-H1 signaling is integrated during CD8+ T cell priming and restrains effector differentiation
|
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Published in |
Cancer Immunology, Immunotherapy, June 2014
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DOI | 10.1007/s00262-014-1563-6 |
Pubmed ID | |
Authors |
Rachel M. Gibbons, Xin Liu, Susan M. Harrington, Christopher J. Krco, Eugene D. Kwon, Haidong Dong |
Abstract |
A promising strategy in tumor immunotherapy is the use of activated dendritic cells as vehicles for tumor vaccines with the goal of activating anti-tumor T cell responses. Current formulations for dendritic cell-based immunotherapies have limited effects on patient survival, providing motivation for further investigation of ways to enhance dendritic cell priming of anti-tumor T cell responses. Using a brief in vitro priming model, we have found that B7-H1 expressed by activated dendritic cells is integrated during priming of naïve CD8(+) T cells and functions to limit the differentiation of effector T cell responses. CD8(+) T cells primed by B7-H1-deficient dendritic cells exhibit increased production of IFN-γ, enhanced target cell killing, and improved anti-tumor activity. Additionally, enhanced memory populations arise from CD8(+) T cells primed by B7-H1-deficient dendritic cells. Based on these findings, we suggest that early blockade of B7-H1 signaling should be investigated as a strategy to improve dendritic cell-based anti-tumor immunotherapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Canada | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Researcher | 1 | 14% |
Student > Bachelor | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 29% |
Psychology | 1 | 14% |
Immunology and Microbiology | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 2 | 29% |