Title |
The Yin and Yang of Bacterial Resilience in the Human Gut Microbiota
|
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Published in |
Journal of Molecular Biology, June 2014
|
DOI | 10.1016/j.jmb.2014.05.029 |
Pubmed ID | |
Authors |
Molly K. Gibson, Mitchell W. Pesesky, Gautam Dantas |
Abstract |
The human gut is home to trillions of microbes that form a symbiotic relationship with the human host. During health, the intestinal microbiota provides many benefits to the host and is generally resistant to colonization by new species; however, disruption of this complex community can lead to pathogen invasion, inflammation, and disease. Restoration and maintenance of a healthy gut microbiota composition requires effective therapies to reduce and prevent colonization of harmful bacteria (pathogens) while simultaneously promoting growth of beneficial bacteria (probiotics). Here we review the mechanisms by which the host modulates the gut community composition during health and disease, and discuss prospects for antibiotic and probiotic therapy for restoration of a healthy intestinal community following disruption. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 5 | 31% |
United States | 2 | 13% |
Australia | 1 | 6% |
Spain | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 63% |
Scientists | 5 | 31% |
Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 2% |
Chile | 1 | <1% |
Netherlands | 1 | <1% |
Korea, Republic of | 1 | <1% |
Canada | 1 | <1% |
Unknown | 200 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 48 | 23% |
Student > Ph. D. Student | 37 | 18% |
Student > Bachelor | 26 | 12% |
Other | 14 | 7% |
Student > Doctoral Student | 13 | 6% |
Other | 48 | 23% |
Unknown | 23 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 68 | 33% |
Biochemistry, Genetics and Molecular Biology | 34 | 16% |
Medicine and Dentistry | 22 | 11% |
Immunology and Microbiology | 20 | 10% |
Social Sciences | 6 | 3% |
Other | 28 | 13% |
Unknown | 31 | 15% |