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Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies

Overview of attention for article published in Frontiers in Genetics, June 2014
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Title
Revisiting glucose uptake and metabolism in schistosomes: new molecular insights for improved schistosomiasis therapies
Published in
Frontiers in Genetics, June 2014
DOI 10.3389/fgene.2014.00176
Pubmed ID
Authors

Hong You, Rachel J. Stephenson, Geoffrey N. Gobert, Donald P. McManus

Abstract

A better understanding of the molecular mechanisms required for schistosomes to take up glucose, the major nutritional source exploited by these blood flukes from their mammalian hosts and the subsequent metabolism required to fuel growth and fecundity, can provide new avenues for developing novel interventions for the control of schistosomiasis. This aspect of parasitism is particularly important to paired adult schistosomes, due to their considerable requirements for the energy needed to produce the extensive numbers of eggs laid daily by the female worm. This review describes recent advances in characterizing glucose metabolism in adult schistosomes. Potential intervention targets are discussed within the insulin signaling and glycolysis pathways, both of which play critical roles in the carbohydrate and energy requirements of schistosomes.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
United Kingdom 1 1%
Unknown 64 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 18%
Student > Ph. D. Student 9 13%
Student > Postgraduate 6 9%
Student > Bachelor 5 7%
Student > Doctoral Student 4 6%
Other 17 25%
Unknown 14 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 25%
Biochemistry, Genetics and Molecular Biology 10 15%
Medicine and Dentistry 7 10%
Chemistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Other 3 4%
Unknown 19 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2014.
All research outputs
#20,231,392
of 22,757,090 outputs
Outputs from Frontiers in Genetics
#8,556
of 11,758 outputs
Outputs of similar age
#193,279
of 228,651 outputs
Outputs of similar age from Frontiers in Genetics
#118
of 126 outputs
Altmetric has tracked 22,757,090 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,651 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.