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X Demographics
Mendeley readers
Attention Score in Context
| Title |
KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
|
|---|---|
| Published in |
Antimicrobial Agents and Chemotherapy, June 2014
|
| DOI | 10.1128/aac.02727-13 |
| Pubmed ID | |
| Authors |
Kelli L. Kuhen, Arnab K. Chatterjee, Matthias Rottmann, Kerstin Gagaring, Rachel Borboa, Jennifer Buenviaje, Zhong Chen, Carolyn Francek, Tao Wu, Advait Nagle, S. Whitney Barnes, David Plouffe, Marcus C. S. Lee, David A. Fidock, Wouter Graumans, Marga van de Vegte-Bolmer, Geert J. van Gemert, Grennady Wirjanata, Boni Sebayang, Jutta Marfurt, Bruce Russell, Rossarin Suwanarusk, Ric N. Price, Francois Nosten, Anchalee Tungtaeng, Montip Gettayacamin, Jetsumon Sattabongkot, Jennifer Taylor, John R. Walker, David Tully, Kailash P. Patra, Erika L. Flannery, Joseph M. Vinetz, Laurent Renia, Robert W. Sauerwein, Elizabeth A. Winzeler, Richard J. Glynne, Thierry T. Diagana |
| Abstract |
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the activity profile of this series the clinical candidate KAF156 shows blood schizonticidal activity with IC50 values of 6-17.4 nM against P. falciparum drug-sensitive and drug-resistant strains as well as potent therapeutic activity in a mouse models of malaria with ED50/90/99 values of 0.6/0.9/1.4 mg/kg respectively. When administered prophylactically in a sporozoite challenge mouse model KAF156 is completely protective as a single oral dose of 10 mg/kg. Finally, KAF156 displays potent Plasmodium transmission blocking activities both in vitro and in vivo. Collectively our data suggest that KAF156, currently under evaluation in clinical trials, has the potential to treat, prevent and block the transmission of malaria. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 173 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Portugal | 1 | <1% |
| Unknown | 170 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 18% |
| Student > Ph. D. Student | 28 | 16% |
| Student > Master | 25 | 14% |
| Student > Bachelor | 13 | 8% |
| Other | 10 | 6% |
| Other | 29 | 17% |
| Unknown | 37 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 37 | 21% |
| Agricultural and Biological Sciences | 31 | 18% |
| Biochemistry, Genetics and Molecular Biology | 21 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 9% |
| Medicine and Dentistry | 11 | 6% |
| Other | 17 | 10% |
| Unknown | 41 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 84. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2022.
All research outputs
#506,401
of 25,394,764 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#145
of 15,582 outputs
Outputs of similar age
#4,413
of 243,494 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#4
of 220 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,582 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,494 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 220 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.