Title |
Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature
|
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Published in |
Digestive Diseases and Sciences, August 2017
|
DOI | 10.1007/s10620-017-4719-3 |
Pubmed ID | |
Authors |
Samuel B. Jackson, Nicholas P. Villano, Jihane N. Benhammou, Michael Lewis, Joseph R. Pisegna, David Padua |
Abstract |
Hereditary hemorrhagic telangiectasia (HHT), also called Osler-Weber-Rendu syndrome, is an autosomal dominant genetic disease that affects the vasculature of numerous organs. The prevalence of HHT is estimated to be between 1.5 and 2 persons per 10,000. While there is still much to learn about this condition, there is an increasing understanding its underlying pathophysiology, genetic basis, presentations, and management. Recognizing that the clinical manifestations of HHT can involve a number of organ systems will provide clinicians with a higher index of suspicion for the disease. This early diagnosis and genotyping can greatly reduce mortality for a patient with HHT through appropriate screening for complications. This review will focus on the gastrointestinal manifestations of HHT and how these can dictate treatment and prognosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 13% |
Student > Postgraduate | 8 | 12% |
Student > Doctoral Student | 6 | 9% |
Other | 5 | 7% |
Student > Ph. D. Student | 4 | 6% |
Other | 9 | 13% |
Unknown | 26 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 40% |
Nursing and Health Professions | 5 | 7% |
Agricultural and Biological Sciences | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Computer Science | 1 | 1% |
Other | 2 | 3% |
Unknown | 25 | 37% |