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Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

Overview of attention for article published in Osteoarthritis and Cartilage, June 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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6 X users
patent
2 patents

Citations

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196 Dimensions

Readers on

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181 Mendeley
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Title
Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state
Published in
Osteoarthritis and Cartilage, June 2014
DOI 10.1016/j.joca.2014.05.021
Pubmed ID
Authors

N. Fahy, M.L. de Vries-van Melle, J. Lehmann, W. Wei, N. Grotenhuis, E. Farrell, P.M. van der Kraan, J.M. Murphy, Y.M. Bastiaansen-Jenniskens, G.J.V.M. van Osch

Abstract

Mesenchymal stem cells (MSCs) are a promising cell type for the repair of damaged cartilage in osteoarthritis (OA). However, OA synovial fluid and factors secreted by synovium impede chondrogenic differentiation of MSCs, and the mechanism responsible for this effect remains unclear. In this study, we sought to investigate whether M1 and M2 synovial macrophages can contribute to the inhibition of MSC chondrogenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
United Kingdom 2 1%
Norway 1 <1%
Italy 1 <1%
Iran, Islamic Republic of 1 <1%
Unknown 174 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 18%
Student > Master 28 15%
Student > Ph. D. Student 26 14%
Student > Bachelor 16 9%
Other 12 7%
Other 31 17%
Unknown 35 19%
Readers by discipline Count As %
Medicine and Dentistry 33 18%
Biochemistry, Genetics and Molecular Biology 27 15%
Agricultural and Biological Sciences 26 14%
Immunology and Microbiology 14 8%
Engineering 11 6%
Other 24 13%
Unknown 46 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2021.
All research outputs
#3,526,523
of 25,373,627 outputs
Outputs from Osteoarthritis and Cartilage
#598
of 3,131 outputs
Outputs of similar age
#33,933
of 243,252 outputs
Outputs of similar age from Osteoarthritis and Cartilage
#5
of 37 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,131 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,252 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.