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The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

Overview of attention for article published in Science, June 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
11 news outlets
blogs
11 blogs
twitter
148 X users
facebook
12 Facebook pages
wikipedia
2 Wikipedia pages
googleplus
2 Google+ users

Citations

dimensions_citation
420 Dimensions

Readers on

mendeley
605 Mendeley
citeulike
8 CiteULike
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Title
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Published in
Science, June 2014
DOI 10.1126/science.1251688
Pubmed ID
Authors

Andrés Moreno-Estrada, Christopher R Gignoux, Juan Carlos Fernández-López, Fouad Zakharia, Martin Sikora, Alejandra V Contreras, Victor Acuña-Alonzo, Karla Sandoval, Celeste Eng, Sandra Romero-Hidalgo, Patricia Ortiz-Tello, Victoria Robles, Eimear E Kenny, Ismael Nuño-Arana, Rodrigo Barquera-Lozano, Gastón Macín-Pérez, Julio Granados-Arriola, Scott Huntsman, Joshua M Galanter, Marc Via, Jean G Ford, Rocío Chapela, William Rodriguez-Cintron, Jose R Rodríguez-Santana, Isabelle Romieu, Juan José Sienra-Monge, Blanca del Rio Navarro, Stephanie J London, Andrés Ruiz-Linares, Rodrigo Garcia-Herrera, Karol Estrada, Alfredo Hidalgo-Miranda, Gerardo Jimenez-Sanchez, Alessandra Carnevale, Xavier Soberón, Samuel Canizales-Quinteros, Héctor Rangel-Villalobos, Irma Silva-Zolezzi, Esteban Gonzalez Burchard, Carlos D Bustamante

Abstract

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.

X Demographics

X Demographics

The data shown below were collected from the profiles of 148 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 605 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 11 2%
Mexico 9 1%
Germany 1 <1%
France 1 <1%
Sweden 1 <1%
South Africa 1 <1%
Switzerland 1 <1%
Canada 1 <1%
Chile 1 <1%
Other 2 <1%
Unknown 576 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 119 20%
Researcher 105 17%
Student > Bachelor 90 15%
Student > Master 77 13%
Other 34 6%
Other 113 19%
Unknown 67 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 208 34%
Biochemistry, Genetics and Molecular Biology 129 21%
Medicine and Dentistry 60 10%
Social Sciences 24 4%
Psychology 11 2%
Other 83 14%
Unknown 90 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 270. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#134,769
of 25,641,627 outputs
Outputs from Science
#4,224
of 83,177 outputs
Outputs of similar age
#1,025
of 244,089 outputs
Outputs of similar age from Science
#42
of 885 outputs
Altmetric has tracked 25,641,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,177 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,089 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 885 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.