Chapter title |
Nucleotide Excision Repair: From Neurodegeneration to Cancer
|
---|---|
Chapter number | 2 |
Book title |
Personalised Medicine
|
Published in |
Advances in experimental medicine and biology, August 2017
|
DOI | 10.1007/978-3-319-60733-7_2 |
Pubmed ID | |
Book ISBNs |
978-3-31-960731-3, 978-3-31-960733-7
|
Authors |
Liakos, Anastasios, Lavigne, Matthieu D., Fousteri, Maria, Anastasios Liakos, Matthieu D. Lavigne, Maria Fousteri |
Abstract |
DNA damage poses a constant threat to genome integrity taking a variety of shapes and arising by normal cellular metabolism or environmental insults. Human syndromes, characterized by increased cancer pre-disposition or early onset of age-related pathology and developmental abnormalities, often result from defective DNA damage responses and compromised genome integrity. Over the last decades intensive research worldwide has made important contributions to our understanding of the molecular mechanisms underlying genomic instability and has substantiated the importance of DNA repair in cancer prevention in the general population. In this chapter, we discuss Nucleotide Excision Repair pathway, the causative role of its components in disease-related pathology and recent technological achievements that decipher mutational landscapes and may facilitate pathological classification and personalized therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Greece | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 27% |
Student > Master | 6 | 18% |
Lecturer | 2 | 6% |
Student > Bachelor | 2 | 6% |
Professor | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 36% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 14 | 42% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Physics and Astronomy | 1 | 3% |
Other | 0 | 0% |
Unknown | 14 | 42% |