Title |
Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids
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Published in |
Journal of Negative Results in BioMedicine, June 2014
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DOI | 10.1186/1477-5751-13-9 |
Pubmed ID | |
Authors |
Jan Lötvall, Eric D Bateman, William W Busse, Paul M O’Byrne, Ashley Woodcock, William T Toler, Loretta Jacques, Caroline Goldfrad, Eugene R Bleecker |
Abstract |
Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (ICS). Findings from a previous 4-week study suggested that VI has inherent 24-hour activity and is therefore suitable for once-daily dosing. The study described here was a double-blind, double-dummy, randomised, placebo-controlled trial, the aim of which was to assess the efficacy of once-daily VI compared with placebo in patients with persistent asthma. The primary endpoint was change from baseline in 24-hour weighted mean forced expiratory volume in 1 second after 12 weeks of treatment vs. placebo. An active control arm received salmeterol (SAL) twice daily. All patients were maintained on a stable background dose of ICS. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 14% |
United States | 1 | 14% |
Argentina | 1 | 14% |
Canada | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 2 | 29% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 71% |
Scientists | 1 | 14% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 8 | 16% |
Researcher | 6 | 12% |
Student > Master | 6 | 12% |
Student > Bachelor | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Other | 9 | 18% |
Unknown | 12 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 44% |
Agricultural and Biological Sciences | 5 | 10% |
Social Sciences | 3 | 6% |
Business, Management and Accounting | 2 | 4% |
Unspecified | 1 | 2% |
Other | 3 | 6% |
Unknown | 14 | 28% |