Title |
Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report
|
---|---|
Published in |
Journal of Medical Case Reports, May 2014
|
DOI | 10.1186/1752-1947-8-159 |
Pubmed ID | |
Authors |
Dumisani Ncomanzi, Rhea Mae R Sicat, Krishnaswamy Sundararajan |
Abstract |
Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. It is recognized as a potential complication of metformin use, particularly in patients with risk factors such as renal dysfunction, liver disease, and heavy alcohol ingestion. These conditions are associated with systemic hypoxemia, which may be caused by cardiorespiratory disease, major surgery, sepsis, dehydration, old age, and overdose. The reported frequency of lactic acidosis is 0.06 per 1000 patient-years, mostly in patients with predisposing factors. This case is important because it details the seriousness of metformin-associated lactic acidosis in a critically ill patient and because, to the best of our knowledge, our patient survived with minimal residual defect despite experiencing a cardiac arrest. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 16% |
Other | 8 | 14% |
Student > Bachelor | 8 | 14% |
Student > Master | 6 | 10% |
Student > Ph. D. Student | 6 | 10% |
Other | 7 | 12% |
Unknown | 14 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 47% |
Nursing and Health Professions | 6 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Chemistry | 2 | 3% |
Other | 3 | 5% |
Unknown | 16 | 28% |