| Title |
Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats
|
|---|---|
| Published in |
Translational Stroke Research, August 2017
|
| DOI | 10.1007/s12975-017-0565-z |
| Pubmed ID | |
| Authors |
Zachary B. Loris, Justin R. Hynton, Andrew A. Pieper, W. Dalton Dietrich |
| Abstract |
Despite ischemic stroke being the fifth leading cause of death in the USA, there are few therapeutic options available. We recently showed that the neuroprotective compound P7C3-A20 reduced brain atrophy, increased neurogenesis, and improved functional recovery when treatment was initiated immediately post-reperfusion after a 90-min middle cerebral artery occlusion (MCAO). In the present study, we investigated a more clinically relevant therapeutic window for P7C3-A20 treatment after ischemic stroke. MCAO rats were administered P7C3-A20 for 1 week, beginning immediately or at a delayed point, 6 h post-reperfusion. Delayed P7C3-A20 treatment significantly improved stroke-induced sensorimotor deficits in motor coordination and symmetry, as well as cognitive deficits in hippocampal-dependent spatial learning, memory retention, and working memory. In the cerebral cortex, delayed P7C3-A20 treatment significantly increased tissue sparing 7 weeks after stroke and reduced hemispheric infarct volumes 48 h after reperfusion. Despite no reduction in striatal infarct volumes acutely, there was a significant increase in spared tissue volume chronically. In the hippocampus, only immediately treated P7C3-A20 animals had a significant increase in tissue sparing compared to vehicle-treated stroke animals. This structural protection translated into minimal hippocampal-dependent behavioral improvements with delayed P7C3-A20 treatment. However, all rats treated with delayed P7C3-A20 demonstrated a significant improvement in both sensorimotor tasks compared to vehicle controls, suggesting a somatosensory-driven recovery. These results demonstrate that P7C3-A20 improves chronic functional and histopathological outcomes after ischemic stroke with an extended therapeutic window. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 18% |
| Researcher | 4 | 14% |
| Student > Master | 4 | 14% |
| Student > Doctoral Student | 3 | 11% |
| Other | 3 | 11% |
| Other | 4 | 14% |
| Unknown | 5 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 4 | 14% |
| Medicine and Dentistry | 3 | 11% |
| Neuroscience | 3 | 11% |
| Nursing and Health Professions | 2 | 7% |
| Unspecified | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 8 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2017.
All research outputs
#20,444,703
of 22,999,744 outputs
Outputs from Translational Stroke Research
#359
of 444 outputs
Outputs of similar age
#276,499
of 316,647 outputs
Outputs of similar age from Translational Stroke Research
#12
of 15 outputs
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