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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
|
|---|---|
| Published in |
Pharmacological Reviews, June 2014
|
| DOI | 10.1124/pr.113.008003 |
| Pubmed ID | |
| Authors |
Rachael Bartlett, Leanne Stokes, Ronald Sluyter |
| Abstract |
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not exclusively, on immune cells. P2X7 activation results in a number of downstream events, including the release of proinflammatory mediators and cell death and proliferation. As such, P2X7 plays important roles in various inflammatory, immune, neurologic and musculoskeletal disorders. This review focuses on the use of P2X7 antagonists in rodent models of neurologic disease and injury, inflammation, and musculoskeletal and other disorders. The cloning and characterization of human, rat, mouse, guinea pig, dog, and Rhesus macaque P2X7, as well as recent observations regarding the gating and permeability of P2X7, are discussed. Furthermore, this review discusses polymorphic and splice variants of P2X7, as well as the generation and use of P2X7 knockout mice. Recent evidence for emerging signaling pathways downstream of P2X7 activation and the growing list of negative and positive modulators of P2X7 activation and expression are also described. In addition, the use of P2X7 antagonists in numerous rodent models of disease is extensively summarized. Finally, the use of P2X7 antagonists in clinical trials in humans and future directions exploring P2X7 as a therapeutic target are described. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 355 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Romania | 1 | <1% |
| Unknown | 350 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 66 | 19% |
| Student > Bachelor | 56 | 16% |
| Researcher | 51 | 14% |
| Student > Master | 39 | 11% |
| Student > Doctoral Student | 24 | 7% |
| Other | 55 | 15% |
| Unknown | 64 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 66 | 19% |
| Agricultural and Biological Sciences | 64 | 18% |
| Medicine and Dentistry | 42 | 12% |
| Neuroscience | 38 | 11% |
| Immunology and Microbiology | 22 | 6% |
| Other | 50 | 14% |
| Unknown | 73 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#6,460,281
of 23,495,502 outputs
Outputs from Pharmacological Reviews
#369
of 666 outputs
Outputs of similar age
#60,366
of 230,359 outputs
Outputs of similar age from Pharmacological Reviews
#5
of 7 outputs
Altmetric has tracked 23,495,502 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 666 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.2. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.