| Title |
Cardioprotective Effects of LCZ696 (Sacubitril/Valsartan) After Experimental Acute Myocardial Infarction
|
|---|---|
| Published in |
JACC: Basic to Translational Science, December 2017
|
| DOI | 10.1016/j.jacbts.2017.08.001 |
| Pubmed ID | |
| Authors |
Masanobu Ishii, Koichi Kaikita, Koji Sato, Daisuke Sueta, Koichiro Fujisue, Yuichiro Arima, Yu Oimatsu, Tatsuro Mitsuse, Yoshiro Onoue, Satoshi Araki, Megumi Yamamuro, Taishi Nakamura, Yasuhiro Izumiya, Eiichiro Yamamoto, Sunao Kojima, Shokei Kim-Mitsuyama, Hisao Ogawa, Kenichi Tsujita |
| Abstract |
LCZ696 (sacubitril/valsartan) can lower the risk of cardiovascular events in chronic heart failure. However, it is unclear whether LCZ696 can improve prognosis in patients with acute myocardial infarction (MI). The present study shows that LCZ696 can prevent cardiac rupture after MI, probably due to the suppression of pro-inflammatory cytokines, matrix metalloproteinase-9 activity and aldosterone production, and enhancement of natriuretic peptides in mice. These findings suggest the mechanistic insight of cardioprotective effects of LCZ696 against acute MI, resulting in the belief that LCZ696 might be useful clinically to improve survival after acute MI. |
X Demographics
The data shown below were collected from the profiles of 56 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 12 | 21% |
| United States | 4 | 7% |
| Mexico | 4 | 7% |
| Colombia | 3 | 5% |
| Venezuela, Bolivarian Republic of | 2 | 4% |
| Italy | 2 | 4% |
| Switzerland | 1 | 2% |
| India | 1 | 2% |
| Canada | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 25 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 35 | 63% |
| Practitioners (doctors, other healthcare professionals) | 15 | 27% |
| Scientists | 4 | 7% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 68 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 24% |
| Student > Master | 9 | 13% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 5 | 7% |
| Student > Postgraduate | 5 | 7% |
| Other | 12 | 18% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 28 | 41% |
| Biochemistry, Genetics and Molecular Biology | 5 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Agricultural and Biological Sciences | 3 | 4% |
| Engineering | 2 | 3% |
| Other | 6 | 9% |
| Unknown | 21 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2020.
All research outputs
#802,493
of 25,621,213 outputs
Outputs from JACC: Basic to Translational Science
#61
of 815 outputs
Outputs of similar age
#18,251
of 450,632 outputs
Outputs of similar age from JACC: Basic to Translational Science
#3
of 14 outputs
Altmetric has tracked 25,621,213 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 815 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.