| Title |
Non-alcoholic fatty liver disease and impaired proinsulin conversion as newly identified predictors of the long-term non-response to a lifestyle intervention for diabetes prevention: results from the TULIP study
|
|---|---|
| Published in |
Diabetologia, August 2017
|
| DOI | 10.1007/s00125-017-4407-z |
| Pubmed ID | |
| Authors |
Vera Schmid, Robert Wagner, Corinna Sailer, Louise Fritsche, Konstantinos Kantartzis, Andreas Peter, Martin Heni, Hans-Ulrich Häring, Norbert Stefan, Andreas Fritsche |
| Abstract |
Lifestyle intervention is effective to prevent type 2 diabetes. However, a considerable long-term non-response occurs to a standard lifestyle intervention. We investigated which risk phenotypes at baseline and their changes during the lifestyle intervention predict long-term glycaemic non-response to the intervention. Of 300 participants at high risk for type 2 diabetes who participated in a 24 month lifestyle intervention with diet modification and increased physical activity, 190 participants could be re-examined after 8.7 ± 1.6 years. All individuals underwent a five-point 75 g OGTT and measurements of body fat compartments and liver fat content with MRI and spectroscopy at baseline, 9 and 24 months during the lifestyle intervention, and at long-term follow-up. Fasting proinsulin to insulin conversion (PI/I ratio) and insulin sensitivity and secretion were calculated from the OGTT. Non-response to lifestyle intervention was defined as no decrease in glycaemia, i.e. no decrease in AUC for glucose at 0-120 min during OGTT (AUCglucose0-120 min). Before the lifestyle intervention, 56% of participants had normal glucose regulation and 44% individuals had impaired fasting glucose and/or impaired glucose tolerance. At long-term follow-up, 11% had developed diabetes. Multivariable regression analysis with adjustment for age, sex, BMI and change in BMI during the lifestyle intervention revealed that baseline insulin secretion and insulin sensitivity, as well as change in insulin sensitivity during the lifestyle intervention, predicted long-term glycaemic control after 9 years. In addition, increased hepatic lipid content as well as impaired fasting proinsulin conversion at baseline were newly detected phenotypes that independently predicted long-term glycaemic control. Increased hepatic lipid content and impaired proinsulin conversion are new predictors, independent of change in body weight, for non-response to lifestyle intervention in addition to the confirmed factors, impaired insulin secretion and insulin sensitivity. |
X Demographics
The data shown below were collected from the profiles of 42 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 12% |
| United States | 5 | 12% |
| Spain | 4 | 10% |
| Germany | 3 | 7% |
| France | 2 | 5% |
| Serbia | 1 | 2% |
| Dominican Republic | 1 | 2% |
| Canada | 1 | 2% |
| India | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 16 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 67% |
| Practitioners (doctors, other healthcare professionals) | 7 | 17% |
| Scientists | 7 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 17% |
| Student > Bachelor | 6 | 13% |
| Student > Doctoral Student | 4 | 9% |
| Professor > Associate Professor | 3 | 6% |
| Student > Master | 3 | 6% |
| Other | 6 | 13% |
| Unknown | 17 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 40% |
| Agricultural and Biological Sciences | 3 | 6% |
| Business, Management and Accounting | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Nursing and Health Professions | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 22 | 47% |
Attention Score in Context
This research output has an Altmetric Attention Score of 86. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2017.
All research outputs
#479,886
of 24,974,461 outputs
Outputs from Diabetologia
#259
of 5,323 outputs
Outputs of similar age
#10,281
of 322,623 outputs
Outputs of similar age from Diabetologia
#15
of 107 outputs
Altmetric has tracked 24,974,461 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,323 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,623 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 107 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.