| Title |
Anti-cancer potential of flavonoids: recent trends and future perspectives
|
|---|---|
| Published in |
3 Biotech, February 2013
|
| DOI | 10.1007/s13205-013-0117-5 |
| Pubmed ID | |
| Authors |
Priya Batra, Anil K. Sharma |
| Abstract |
Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan and etoposide are in clinical use all over the world. Other promising anti-cancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol. From this list one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic and prostate cancer. Flavonoids present in human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. A positive correlation between flavonoids-rich diet (from vegetables and fruits) and lower risk of colon, prostate and breast cancers lead to a question that whether flavonoids mediate the protective effects as chemopreventive agents or can interact with different genes and proteins to play role in chemotherapy. The current review emphasizes onto the therapeutic potential of flavonoids and their synthetic analogs as anti-cancer agents by providing new insights into the factors, regulation and molecular mechanisms along with their significant protein interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 683 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | <1% |
| India | 1 | <1% |
| Mauritius | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 678 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 111 | 16% |
| Student > Bachelor | 98 | 14% |
| Student > Master | 96 | 14% |
| Researcher | 58 | 8% |
| Student > Doctoral Student | 39 | 6% |
| Other | 105 | 15% |
| Unknown | 176 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 122 | 18% |
| Biochemistry, Genetics and Molecular Biology | 101 | 15% |
| Chemistry | 76 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 71 | 10% |
| Medicine and Dentistry | 46 | 7% |
| Other | 67 | 10% |
| Unknown | 200 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#887,843
of 23,852,694 outputs
Outputs from 3 Biotech
#11
of 1,305 outputs
Outputs of similar age
#8,003
of 293,696 outputs
Outputs of similar age from 3 Biotech
#2
of 4 outputs
Altmetric has tracked 23,852,694 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,305 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 293,696 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.