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Incompletely matched influenza vaccine still provides protection in frail elderly

Overview of attention for article published in Vaccine, April 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
3 news outlets
policy
1 policy source

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
61 Mendeley
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Title
Incompletely matched influenza vaccine still provides protection in frail elderly
Published in
Vaccine, April 2009
DOI 10.1016/j.vaccine.2009.03.024
Pubmed ID
Authors

Anna S. Dean, Cameron R.M. Moffatt, Alexander Rosewell, Dominic E. Dwyer, Richard I. Lindley, Robert Booy, C. Raina MacIntyre

Abstract

A cluster-randomised controlled trial of antiviral treatment to control influenza outbreaks in aged-care facilities (ACFs) provided an opportunity to assess VE in the frail, institutionalised elderly. Data were pooled from five influenza outbreaks in 2007. Rapid testing methods for influenza were used to confirm outbreaks and/or identify further cases. Vaccination coverage among ACF residents ranged from 59% to 100%, whereas it was consistently low in staff (11-33%). The attack rates for laboratory-confirmed influenza in residents ranged from 9% to 24%, with the predominate strain determined to be influenza A. Sequencing of the hemagglutinin gene from a sub-sample demonstrated an incomplete match with the 2007 southern hemisphere influenza vaccine. Influenza VE was estimated to be 61% (95%CI 6%, 84%) against laboratory-confirmed influenza, 51% (95%CI -16%, 79%) against influenza-like illness, 82% (95%CI 27%, 96%) against pneumonia-related and influenza-related hospitalisations and 71% (95%CI -28%, 95%) against death from all causes. This supports the continued policy of targeted vaccination of the institutionalised, frail elderly. There is also reassurance that influenza vaccine can be effective against disease and severe outcomes, despite an incomplete vaccine match. This benefit is additional to protection from antivirals.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 60 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 20%
Student > Ph. D. Student 11 18%
Student > Bachelor 9 15%
Student > Master 5 8%
Other 3 5%
Other 15 25%
Unknown 6 10%
Readers by discipline Count As %
Medicine and Dentistry 24 39%
Agricultural and Biological Sciences 11 18%
Biochemistry, Genetics and Molecular Biology 3 5%
Immunology and Microbiology 3 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 7 11%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2016.
All research outputs
#1,497,750
of 25,374,647 outputs
Outputs from Vaccine
#1,262
of 16,509 outputs
Outputs of similar age
#4,082
of 106,931 outputs
Outputs of similar age from Vaccine
#6
of 120 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 16,509 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.