Title |
Fast Virtual Fractional Flow Reserve Based Upon Steady-State Computational Fluid Dynamics Analysis Results From the VIRTU-Fast Study
|
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Published in |
JACC: Basic to Translational Science, August 2017
|
DOI | 10.1016/j.jacbts.2017.04.003 |
Pubmed ID | |
Authors |
Paul D. Morris, Daniel Alejandro Silva Soto, Jeroen F.A. Feher, Dan Rafiroiu, Angela Lungu, Susheel Varma, Patricia V. Lawford, D. Rodney Hose, Julian P. Gunn |
Abstract |
Fractional flow reserve (FFR)-guided percutaneous intervention is superior to standard assessment but remains underused. The authors have developed a novel "pseudotransient" analysis protocol for computing virtual fractional flow reserve (vFFR) based upon angiographic images and steady-state computational fluid dynamics. This protocol generates vFFR results in 189 s (cf >24 h for transient analysis) using a desktop PC, with <1% error relative to that of full-transient computational fluid dynamics analysis. Sensitivity analysis demonstrated that physiological lesion significance was influenced less by coronary or lesion anatomy (33%) and more by microvascular physiology (59%). If coronary microvascular resistance can be estimated, vFFR can be accurately computed in less time than it takes to make invasive measurements. |
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