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Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Overview of attention for article published in Nature, June 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

news
10 news outlets
blogs
1 blog
twitter
31 X users
facebook
3 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
105 Dimensions

Readers on

mendeley
236 Mendeley
citeulike
1 CiteULike
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Title
Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs
Published in
Nature, June 2014
DOI 10.1038/nature13289
Pubmed ID
Authors

Javier Lopez-Rios, Amandine Duchesne, Dario Speziale, Guillaume Andrey, Kevin A. Peterson, Philipp Germann, Erkan Ünal, Jing Liu, Sandrine Floriot, Sarah Barbey, Yves Gallard, Magdalena Müller-Gerbl, Andrew D. Courtney, Christophe Klopp, Sabrina Rodriguez, Robert Ivanek, Christian Beisel, Carol Wicking, Dagmar Iber, Benoit Robert, Andrew P. McMahon, Denis Duboule, Rolf Zeller

Abstract

The large spectrum of limb morphologies reflects the wide evolutionary diversification of the basic pentadactyl pattern in tetrapods. In even-toed ungulates (artiodactyls, including cattle), limbs are adapted for running as a consequence of progressive reduction of their distal skeleton to symmetrical and elongated middle digits with hoofed phalanges. Here we analyse bovine embryos to establish that polarized gene expression is progressively lost during limb development in comparison to the mouse. Notably, the transcriptional upregulation of the Ptch1 gene, which encodes a Sonic hedgehog (SHH) receptor, is disrupted specifically in the bovine limb bud mesenchyme. This is due to evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development. Our study provides a molecular explanation for the loss of digit asymmetry in bovine limb buds and suggests that modifications affecting the Ptch1 cis-regulatory landscape have contributed to evolutionary diversification of artiodactyl limbs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 3%
Brazil 1 <1%
South Africa 1 <1%
Switzerland 1 <1%
Taiwan 1 <1%
United Kingdom 1 <1%
Spain 1 <1%
China 1 <1%
Unknown 222 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 25%
Researcher 37 16%
Student > Master 28 12%
Student > Bachelor 17 7%
Student > Doctoral Student 16 7%
Other 39 17%
Unknown 40 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 108 46%
Biochemistry, Genetics and Molecular Biology 54 23%
Medicine and Dentistry 8 3%
Neuroscience 4 2%
Physics and Astronomy 3 1%
Other 15 6%
Unknown 44 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 96. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2017.
All research outputs
#443,965
of 25,587,485 outputs
Outputs from Nature
#21,077
of 98,310 outputs
Outputs of similar age
#3,816
of 243,304 outputs
Outputs of similar age from Nature
#291
of 1,012 outputs
Altmetric has tracked 25,587,485 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,310 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,304 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,012 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.