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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification
|
|---|---|
| Published in |
JACC: Basic to Translational Science, August 2017
|
| DOI | 10.1016/j.jacbts.2017.03.015 |
| Pubmed ID | |
| Authors |
Bin Yu, Anouar Hafiane, George Thanassoulis, Leah Ott, Nial Filwood, Marta Cerruti, Ophélie Gourgas, Dominique Shum-Tim, Hamood Al Kindi, Benoit de Varennes, Alawi Alsheikh-Ali, Jacques Genest, Adel Schwertani |
| Abstract |
Lipoprotein(a), or Lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased SOX9 and matrix Gla protein (p < 0.001). Inhibition of MAPK38 and GSK3β significantly reduced Lp(a)-induced calcification of human aortic valve interstitial cells (p < 0.001). There was abundant presence of Lp(a) and E06 immunoreactivity in diseased human aortic valves. The present study demonstrates a causal effect for Lp(a) in aortic valve calcification and suggests that interfering with the Lp(a)pathway could provide a novel therapeutic approach in the management of this debilitating disease. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 33% |
| Spain | 3 | 10% |
| Canada | 3 | 10% |
| United Kingdom | 2 | 7% |
| Australia | 2 | 7% |
| Ecuador | 1 | 3% |
| Germany | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Unknown | 7 | 23% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 50% |
| Scientists | 9 | 30% |
| Practitioners (doctors, other healthcare professionals) | 5 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 18% |
| Researcher | 11 | 15% |
| Student > Doctoral Student | 10 | 14% |
| Student > Ph. D. Student | 9 | 12% |
| Student > Master | 7 | 9% |
| Other | 7 | 9% |
| Unknown | 17 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 26% |
| Biochemistry, Genetics and Molecular Biology | 12 | 16% |
| Agricultural and Biological Sciences | 10 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
| Engineering | 3 | 4% |
| Other | 4 | 5% |
| Unknown | 22 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2017.
All research outputs
#2,135,997
of 25,382,440 outputs
Outputs from JACC: Basic to Translational Science
#188
of 799 outputs
Outputs of similar age
#40,022
of 324,143 outputs
Outputs of similar age from JACC: Basic to Translational Science
#3
of 15 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,143 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.