You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression
|
|---|---|
| Published in |
Pharmacology, Biochemistry & Behavior, November 2010
|
| DOI | 10.1016/j.pbb.2010.11.012 |
| Pubmed ID | |
| Authors |
Cliona M. O'Mahony, Gerard Clarke, Sinead Gibney, Timothy G. Dinan, John F. Cryan |
| Abstract |
The neurochemical basis of depression focuses on alterations in the monoaminergic and amino acid neurotransmitter systems. Moreover, decreases in serum levels of the neurotrophin brain-derived neurotrophic factor (BDNF) have led to the more recent neurotrophic hypothesis of depression. Chronic stress is one of the major predisposing factors to developing the disorder and thus we investigated the impact of chronic restraint stress on the levels of several neurotransmitters and their metabolites in a genetic animal model of depression, the Wistar Kyoto (WKY) rat. Behavioural analysis of WKY rats indicated both a depressive and anxiety-like phenotype compared to their Sprague Dawley (SD) controls. WKY animals showed similar stress-induced decreases in hippocampal GABA, noradrenaline and dopamine as their SD counterparts while exhibiting a divergent decrease in 5-HT, 5-HIAA and DOPAC. WKY rats also showed a stress-dependent increase in GABA concentrations in the amygdala compared to the SD animals. Moreover, WKY but not SD rats had a chronic stress-induced decrease in serum BDNF levels. Together these data show that there are specific strain-dependent changes in neurotransmitter and neurotrophin levels in response to chronic stress which may predispose WKY animals to a depressive-like phenotype. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 1% |
| Malaysia | 1 | 1% |
| Netherlands | 1 | 1% |
| Ireland | 1 | 1% |
| South Africa | 1 | 1% |
| India | 1 | 1% |
| United Kingdom | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 91 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 24% |
| Researcher | 17 | 17% |
| Student > Bachelor | 13 | 13% |
| Student > Master | 11 | 11% |
| Student > Doctoral Student | 6 | 6% |
| Other | 16 | 16% |
| Unknown | 12 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 24% |
| Medicine and Dentistry | 19 | 19% |
| Neuroscience | 18 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 9 | 9% |
| Unknown | 18 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2011.
All research outputs
#17,286,379
of 25,374,647 outputs
Outputs from Pharmacology, Biochemistry & Behavior
#2,560
of 3,159 outputs
Outputs of similar age
#150,616
of 188,640 outputs
Outputs of similar age from Pharmacology, Biochemistry & Behavior
#15
of 17 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,159 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 188,640 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.