Title |
Proposed new clinicopathological surrogate definitions of luminal A and luminal B (HER2-negative) intrinsic breast cancer subtypes
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Published in |
Breast Cancer Research, June 2014
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DOI | 10.1186/bcr3679 |
Pubmed ID | |
Authors |
Patrick Maisonneuve, Davide Disalvatore, Nicole Rotmensz, Giuseppe Curigliano, Marco Colleoni, Silvia Dellapasqua, Giancarlo Pruneri, Mauro G Mastropasqua, Alberto Luini, Fabio Bassi, Gianmatteo Pagani, Giuseppe Viale, Aron Goldhirsch |
Abstract |
The St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 recognized substantial progress in the pathological characterization of breast cancer subtypes. A useful surrogate definition was developed to distinguish luminal A-like breast cancer from luminal B-like disease based on a combination of estrogen receptor (ER), progesterone receptor (PgR) and Ki-67 status, without a requirement for molecular diagnostics. Differences depend upon the choice of the threshold value for Ki-67 and the requirement for substantial PgR positivity. We aimed to verify the suitability of the new surrogate definitions of luminal subtypes in terms of distant disease control in a large series of patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 25% |
Mexico | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 148 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 19 | 13% |
Student > Ph. D. Student | 18 | 12% |
Researcher | 18 | 12% |
Student > Bachelor | 17 | 11% |
Student > Postgraduate | 12 | 8% |
Other | 43 | 29% |
Unknown | 23 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 71 | 47% |
Biochemistry, Genetics and Molecular Biology | 21 | 14% |
Agricultural and Biological Sciences | 9 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
Nursing and Health Professions | 4 | 3% |
Other | 11 | 7% |
Unknown | 28 | 19% |