| Title |
The association of comorbid conditions with patient-reported outcomes in Veterans with hip and knee osteoarthritis
|
|---|---|
| Published in |
Clinical Rheumatology, June 2014
|
| DOI | 10.1007/s10067-014-2707-y |
| Pubmed ID | |
| Authors |
Leah L. Zullig, Hayden B. Bosworth, Amy S. Jeffreys, Leonor Corsino, Cynthia J. Coffman, Eugene Z. Oddone, William S. Yancy, Kelli D. Allen |
| Abstract |
There is limited understanding of how comorbid health conditions affect osteoarthritis (OA)-related outcomes. This study examined associations of different comorbidity measures with baseline OA-related patient-reported outcomes (PROs) among patients with hip and knee OA. Data were from patients (N = 300, 9 % female, mean age = 61.1; SD = 9.2) enrolled in a randomized control trial at the Durham Veterans Affairs Medical Center. Separate multivariable regression models, adjusted for demographic and clinical characteristics, examined the association of each comorbidity measure with baseline PROs: pain, physical function, depressive symptoms, fatigue, and insomnia. Comorbidity measures included the Self-Administered Comorbidity Questionnaire (SACQ), conditions reported as activity-limiting (SACQ-AL), and indicators of depression, diabetes, hypertension, and back pain. Mean (SD) numbers of comorbid conditions and activity-limiting conditions were 3.4 (1.8) and 1.6 (1.4), respectively. Comorbidity scores (SACQ overall and SACQ-AL) and individual comorbidity conditions were each associated with worse OA-related PROs adjusting for demographic and clinical factors. Worse SACQ overall and SACQ-AL scores were associated with worse mean scores for pain, depressive symptoms, fatigue, and insomnia (p values <0.01). Additionally, increasing SACQ-AL scores were associated with worse mean scores for function (p < 0.01). Depression was associated with worse pain (p = 0.03), fatigue, and insomnia (p values <0.01). Diabetes was associated with worse fatigue (p = 0.01), depressive symptoms (p = 0.02), and insomnia (p = 0.03). Back pain was associated with worse pain scores (p = 0.02). Results provide evidence that comorbidity burden, particularly activity-limiting conditions, is associated with worse OA-related PROs. Interventions for patients with OA need to address comorbid conditions and their impact on key outcomes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | <1% |
| Unknown | 130 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 14% |
| Student > Master | 15 | 11% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 7 | 5% |
| Other | 20 | 15% |
| Unknown | 50 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 21% |
| Nursing and Health Professions | 19 | 15% |
| Sports and Recreations | 7 | 5% |
| Psychology | 7 | 5% |
| Neuroscience | 4 | 3% |
| Other | 15 | 11% |
| Unknown | 52 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2014.
All research outputs
#15,302,068
of 22,757,541 outputs
Outputs from Clinical Rheumatology
#1,977
of 2,989 outputs
Outputs of similar age
#133,533
of 228,693 outputs
Outputs of similar age from Clinical Rheumatology
#18
of 53 outputs
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We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.