| Title |
PPAR-γ and Akt regulate GLUT1 and GLUT3 surface localization during Mycobacterium tuberculosis infection
|
|---|---|
| Published in |
Molecular and Cellular Biochemistry, August 2017
|
| DOI | 10.1007/s11010-017-3161-3 |
| Pubmed ID | |
| Authors |
Shyamashree Dasgupta, Ramesh Chandra Rai |
| Abstract |
The success of Mycobacterium tuberculosis (Mtb) as a pathogen stems from its ability to manipulate the host macrophage towards increased lipid biogenesis and lipolysis inhibition. Inhibition of lipolysis requires augmented uptake of glucose into the host cell causing an upregulation of the glucose transporters GLUT1 and GLUT3 on the cell surface. Mechanism behind this upregulation of the GLUT proteins during Mtb infection is hitherto unknown and demands intensive investigation in order to understand the pathways linked with governing them. Our endeavor to investigate some of the key proteins that have been found to be affected during Mtb infection led us to investigate host molecular pathways such as Akt and PPAR-γ that remain closely associated with the survival of the bacilli by modulating the localization of glucose transporters GLUT1 and GLUT3. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Researcher | 8 | 21% |
| Student > Master | 6 | 15% |
| Student > Doctoral Student | 5 | 13% |
| Student > Bachelor | 4 | 10% |
| Other | 2 | 5% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 28% |
| Immunology and Microbiology | 9 | 23% |
| Medicine and Dentistry | 4 | 10% |
| Neuroscience | 2 | 5% |
| Chemistry | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 7 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#20,444,703
of 22,999,744 outputs
Outputs from Molecular and Cellular Biochemistry
#1,818
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Outputs of similar age
#275,890
of 315,948 outputs
Outputs of similar age from Molecular and Cellular Biochemistry
#26
of 38 outputs
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