Title |
The inheritance of Tourette Disorder: A review
|
---|---|
Published in |
Journal of Obsessive Compulsive and Related Disorders, October 2014
|
DOI | 10.1016/j.jocrd.2014.06.003 |
Pubmed ID | |
Authors |
David L. Pauls, Thomas V. Fernandez, Carol A. Mathews, Matthew W. State, Jeremiah M. Scharf |
Abstract |
Georges Gilles de la Tourette, in describing the syndrome that now bears his name, observed that the condition aggregated within families. Over the last three decades, numerous studies have confirmed this observation, and demonstrated that familial clustering is due in part to genetic factors. Recent studies are beginning to provide clues about the underlying genetic mechanisms important for the manifestation of some cases of Tourette Disorder (TD). Evidence has come from different study designs, such as nuclear families, twins, multigenerational families, and case-control samples, together examining the broad spectrum of genetic variation including cytogenetic abnormalities, copy number variants, genome-wide association of common variants, and sequencing studies targeting rare and/or de novo variation. Each of these classes of genetic variation holds promise for identifying the causative genes and biological pathways contributing to this paradigmatic neuropsychiatric disorder. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Unknown | 80 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 19% |
Student > Ph. D. Student | 14 | 17% |
Student > Doctoral Student | 7 | 9% |
Student > Bachelor | 7 | 9% |
Student > Master | 5 | 6% |
Other | 16 | 20% |
Unknown | 17 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 27% |
Agricultural and Biological Sciences | 13 | 16% |
Psychology | 9 | 11% |
Neuroscience | 8 | 10% |
Social Sciences | 4 | 5% |
Other | 7 | 9% |
Unknown | 18 | 22% |